Monobactam
Monobactams are β-lactam compounds wherein the β-lactam ring is alone and not fused to another ring, in contrast to most other β-lactams. They are effective only against aerobic Gram-negative bacteria (e.g., Neisseria, Pseudomonas).
The only commercially available monobactam antibiotic is aztreonam.
Other examples of monobactams are tigemonam,[1] nocardicin A, and tabtoxin.
Adverse effects to monobactams can include skin rash and occasional abnormal liver functions.
They have no cross-hypersensitivity reactions with penicillin but like penicillins can trigger seizures in patients with history of seizures.
References
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External links
- Monobactams at the US National Library of Medicine Medical Subject Headings (MeSH)
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