Muzolimine
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Muzolimine is a High-ceiling loop diuretic.[1] It is a pyrazole diuretic which was used for treatment of hypertension but was withdrawn worldwide because of severe neurological side effects.[2]
Synthesis
File:Muzolimine synthesis.svg
Muzolimine synthesis:[3]
Rxn of (1-(3,4-dichlorophenyl)ethyl)hydrazine (1) with ethyl 3-amino-3-ethoxyacrylate (2) leads to a ring-forming two-site reaction and formation of the pyrazoline diuretic agent, muzolimine (3).
References
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- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ E. Möller et al., DE 2319278; eidem, U.S. Patent 3,957,814 (1974, 1976 both to Bayer); eidem, Experientia 33, 382 (1977).
