SOCS2
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene.[1][2][3]
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma (IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling.[4] Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.[3][5]
Interactions
SOCS2 has been shown to interact with Insulin-like growth factor 1 receptor[4] and Erythropoietin receptor.[6]
References
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PDB gallery
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External links
- SOCS2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it. |
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