IRF4
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Interferon regulatory factor 4 also known as MUM1 is a protein that in humans is encoded by the IRF4 gene,[1][2][3] located at 6p25-p23.
The MUM1 symbol is polysemous; although it is an older synonym for IRF4 (HGNC:6119), it is also the current HGNC official symbol for melanoma associated antigen (mutated) 1 (HGNC:29641; located at 19p13.3).
Clinical significance
In melanocytic cells the IRF4 gene may be regulated by MITF.[4] IRF4 is a transcription factor that has been implicated in acute leukemia.[5] This gene is strongly associated with pigmentation: sensitivity of skin to sun exposure, freckles, blue eyes, and brown hair color.[6] A variant has been implicated in greying of hair.[7]
Interactions
IRF4 has been shown to interact with:
See also
References
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External links
- FactorBook IRF4
- IRF4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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