Bay K8644
From Infogalactic: the planetary knowledge core
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Names | |
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IUPAC name
Methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate
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Identifiers | |
71145-03-4 ![]() |
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ChEMBL | ChEMBL513599 ![]() |
ChemSpider | 2213 ![]() |
2511 | |
Jmol 3D model | Interactive image |
PubChem | 2303 |
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Properties | |
C16H15F3N2O4 | |
Molar mass | 356.30 g·mol−1 |
Insoluble | |
Solubility in other solvents | DMSO: 184 mg/mL; methanol and ethanol: 63 mg/mL |
Vapor pressure | {{{value}}} |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references | |
Bay K8644 is a chemical compound that functions as a calcium channel agonist. Bay K8644 is used primarily as a biochemical research tool for this effect.[2] It is a structural analog of nifedipine with positive inotropic activity, and as an aromatic it is highly lipid soluble.
Mechanism of Action
Bay K8644 targets Voltage-sensitive dihydropyridine (DHP) Calcium Channels (L-Type). It is the first positive inotropic agent shown to act specifically and directly on calcium channels.[3]
References
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- ↑ (±)-Bay K8644 at Sigma-Aldrich
- ↑ Bay K8644 at PubChem
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
Categories:
- Pages with reference errors
- Articles without KEGG source
- Articles without UNII source
- Articles with changed InChI identifier
- Pages using collapsible list with both background and text-align in titlestyle
- Dihydropyridines
- Organofluorides
- Methyl esters
- Calcium channel openers
- Nitro compounds
- Organic compound stubs