Ralfinamide

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Not to be confused with Rufinamide.
Ralfinamide
Ralfinamide.svg
Systematic (IUPAC) name
N2-{4-[(2-Fluorobenzyl)oxy]benzyl}-L-alaninamide
Identifiers
CAS Number 133865-88-0
ATC code None
PubChem CID: 5745207
ChemSpider 4676525
ChEMBL CHEMBL2107771
Chemical data
Formula C17H19FN2O2
Molecular mass 302.343 g/mol
  • C[C@@H](C(=O)N)NCc1ccc(cc1)OCc2ccccc2F
  • InChI=1S/C17H19FN2O2/c1-12(17(19)21)20-10-13-6-8-15(9-7-13)22-11-14-4-2-3-5-16(14)18/h2-9,12,20H,10-11H2,1H3,(H2,19,21)/t12-/m0/s1
  • Key:BHJIBOFHEFDSAU-LBPRGKRZSA-N

Ralfinamide (INN) (code names NW-1029, FCE-26742A, PNU-0154339E)[1] is a multimodal drug which is under investigation by Newron Pharmaceuticals for the treatment of neuropathic pain and other pain conditions such as post-operative dental pain.[2][3][4][5]

It has a relatively complex pharmacology, acting as a mixed voltage-gated sodium channel blocker (including Nav1.7),[2][3] N-type calcium channel blocker,[2][3] noncompetitive NMDA receptor antagonist,[6] and monoamine oxidase B inhibitor.[7][8]

It has thus far progressed as far as phase IIb/phase III clinical trials.[5][9] In 2010 it failed a phase II trial for lower back pain.[10] Encouraging Phase II results have been announced for neuropathic pain.[11]

See also

References

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External links


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  2. ↑ 2.0 2.1 2.2 Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ 3.0 3.1 3.2 Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  5. ↑ 5.0 5.1 Lua error in package.lua at line 80: module 'strict' not found.
  6. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  7. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  8. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  9. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  10. ↑ Newron reports SERENA trial top-line results for ralfinamide
  11. ↑ Newron Announces Positive Results With Ralfinamide From Phase II Trial in Neuropathic Pain
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