Leconotide
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Leconotide (INN) (code names CNSB004, AM336), also known as ω-conotoxin CVID, is an ω-conotoxin peptide isolated from the venom of Conus catus which is under investigation as an analgesic drug for the treatment of pain conditions.[1][2]
It acts as an N-type voltage-gated calcium channel (Cav2.2) blocker, and is highly selective for this channel over the related P/Q-type voltage-gated calcium channel (Cav2.1).[1][2]
Relative to ziconotide, leconotide is advantageous in that it is significantly less toxic, and for that reason can be administered intravenously as opposed to via intrathecal injection.[3][4][5]
See also
- Ziconotide, an analgesic peptide derived from the toxin of the cone snail species Conus magus
- Lacosamide, an approved small molecule analgesic and anti-epileptic
- Ralfinamide, an investigational small molecule analgesic
References
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