GPR182

G protein-coupled receptor 182
Identifiers
Symbols	GPR182 ; 7TMR; ADMR; AM-R; AMR; G10D; gamrh; hrhAMR
External IDs	OMIM: 605307 MGI: 109545 HomoloGene: 5255 IUPHAR: 146 ChEMBL: 4356 GeneCards: GPR182 Gene
Gene ontology Molecular function • adrenomedullin receptor activity • transmembrane signaling receptor activity • G-protein coupled receptor activity Cellular component • intracellular • plasma membrane • integral component of membrane Biological process • response to hypoxia • cell surface receptor signaling pathway • G-protein coupled receptor signaling pathway • intracellular signal transduction Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11318	11536
Ensembl	ENSG00000166856	ENSMUSG00000058396
UniProt	O15218	P43142
RefSeq (mRNA)	NM_007264	NM_007412
RefSeq (protein)	NP_009195	NP_031438
Location (UCSC)	Chr 12: 56.99 – 57 Mb	Chr 10: 127.75 – 127.75 Mb
PubMed search	[1]	[2]

GPR182 (or G protein-coupled receptor 182) is a human gene (and associated protein) which is an orphan G-protein coupled receptor.

When this gene was first cloned, it was proposed to encode an adrenomedullin receptor. However, when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM).

It was subsequently shown that a different GPCR, CALCRL when complexed with RAMP2 can function as an ADM receptor.