Prostaglandin F receptor
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Prostaglandin F receptor (FP) is a receptor for Prostaglandin F2α. It is encoded by the gene PTGFR.[1]
It is a member of the G-protein coupled receptor family. Activation of FP Receptor results in activation of G-protein subunit Gq, increasing IP3 and DAG.
Two transcript variants encoding different isoforms have been found for this gene.[1]
Functions
Main effects of prostaglandin binding to the receptor are:
- uterine contraction
- bronchoconstriction[2]
Via activation of this receptor, PGF2-alpha mediates luteolysis,[1] and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus and gastrointestinal tract sphincters.[3]
Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor in ovarian luteal cells initiates luteolysis and thus induces parturition.[4]
See also
References
- ↑ 1.0 1.1 1.2 Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Pharmacology, (Rang, Dale, Ritter & Moore, ISBN 0-443-07145-4, 5th ed., Churchill Livingstone 2003) Page 234
- ↑ Signal transduction in lower esophageal sphincter circular muscle Piero Biancani, Ph.D. and Karen M. Harnett, Ph.D.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
External links
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Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
