PKN3 (gene)

Protein kinase N3
Identifiers
Symbols	PKN3 ; UTDP4-1
External IDs	OMIM: 610714 MGI: 2388285 HomoloGene: 50980 GeneCards: PKN3 Gene
EC number	2.7.11.13
Gene ontology Molecular function • protein kinase activity • protein kinase C activity • protein binding • ATP binding Cellular component • nucleus • Golgi apparatus • perinuclear region of cytoplasm Biological process • protein phosphorylation • signal transduction • epithelial cell migration Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE PKN3 gnf1h00136 at tn.png
File:PBB GE PKN3 gnf1h00137 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	29941	263803
Ensembl	ENSG00000160447	ENSMUSG00000026785
UniProt	Q6P5Z2	Q8K045
RefSeq (mRNA)	NM_013355	NM_153805
RefSeq (protein)	NP_037487	NP_722500
Location (UCSC)	Chr 9: 128.7 – 128.72 Mb	Chr 2: 30.08 – 30.09 Mb
PubMed search	[1]	[2]

PKN3 is a protein kinase C-related molecule and thought to be an effector mediating malignant cell growth downstream of activated phosphoinositide 3-kinase (PI3K). It is thought that chronic activation of the phosphoinositide 3-kinase (PI3K)/PTEN signal transduction pathway contributes to metastatic cell growth and that PKN3 may mediate that growth.1

PKN3 is required for invasive prostate cell growth as assessed by 3D cell culture assays and in an orthotopic mouse tumor model by inducible expression of short hairpin RNA (shRNA). PKN3 may represent a target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of PI3K.

Interactions

PKN3 (gene) has been shown to interact with ARHGAP26.