RPS6KA3
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Ribosomal protein S6 kinase, 90kDa, polypeptide 3, also known as RPS6KA3, is an enzyme that in humans is encoded by the RPS6KA3 gene.[1][2]
Contents
Function
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation.[1]
Clinical significance
Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS).[3]
Interactions
RPS6KA3 has been shown to interact with CREB-binding protein,[4] MAPK1[5][6] and PEA15.[7]
References
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External links
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