ZAK
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Sterile alpha motif and leucine zipper containing kinase AZK, also known as ZAK, is a human gene.[1]
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[1]
Interactions
ZAK has been shown to interact with ZNF33A.[2]
References
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