RTI-32

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(–)-2β-Carbomethoxy-3β-(4-tolyl)tropane (RTI-32, tolpane) is a phenyltropane-based cocaine analog that is important in the field of medicinal chemistry for performing SAR.

It has similar properties in vitro to related drugs such as RTI-31.[1]

Whereas the potency of RTI-31 has been quoted as being as high as 64 x cocaine, RTI-32 is not anything like this strong.

Comparison of Data
Compound DAT DA NET NA SERT 5HT ED50
Troparil 23 49.8 550 37.2 178 173 0.34
RTI-32 1.7 7.02 36 8.42 23 19.4 0.31
RTI-31 1.1 3.68 22 5.86 4.0 5.0 0.13
3'4'-xylyl 0.43 unknown 44 unknown 2.42 unknown

Further Analogues

Another good source to read is:[2]

See also

References

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  1. ↑ Remy P, Doder M, Lees A, Turjanski N, Brooks D. Depression in Parkinson's disease: loss of dopamine and noradrenaline innervation in the limbic system. Brain. 2005 Jun;128(Pt 6):1314-22. PMID 15716302
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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