THIQ

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This article is about the selective MC4 agonist. For the heterocyclic amine, see Tetrahydroisoquinoline.
THIQ
THIQ structure.png
Systematic (IUPAC) name
N-[(3R)-1,2,3,4-tetrahydroisoquinolinium-3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl) -2-[4-cyclohexyl-4-(1H-1,2,4-triazol-1ylmethyl)piperidin-1-yl]-2-oxoethylamine
Identifiers
CAS Number 312637-48-2 YesY
PubChem CID: 9938402
IUPHAR/BPS 1338
Chemical data
Formula C33H41ClN6O2
Molecular mass 589.169
  • N4Cc1ccccc1CC4C(=O)NC(Cc(cc2)ccc2Cl)C(=O)N5CCC(CC5)(Cn6ncnc6)C3CCCCC3
  (verify)

THIQ is a drug used in scientific research, which is the first non-peptide agonist developed that is selective for the melanocortin receptor subtype MC4.[1][2] In animal studies, THIQ stimulated sexual activity in rats,[3] but with little effect on appetite or inflammation.[4] This supports possible application of MC4 selective agonists for the treatment of sexual dysfunction in humans,[5] although THIQ itself has poor oral bioavailability and a short duration of action so improved analogues will need to be developed.[6]

See also

References

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