Tolrestat

Tolrestat

Systematic (IUPAC) name
N-{[6-methoxy-5-(trifluoromethyl)-1-naphthyl]carbothioyl}-N-methylglycine
Clinical data
Legal status	Withdrawn from market
Identifiers
CAS Number	82964-04-3 Y
ATC code	A10XA01 (WHO)
PubChem	CID: 53359
IUPHAR/BPS	7404
UNII	0T93LG5NMK N
KEGG	D02323 Y
ChEMBL	CHEMBL436 N
Chemical data
Formula	C16H14F3NO3S
Molecular mass	357.34 g/mol
SMILES CN(CC(=O)O)C(=S)C1=CC=CC2=C1C=CC(=C2C(F)(F)F)OC
NY (what is this?)  (verify)

Tolrestat (INN) (AY-27773) is an aldose reductase inhibitor which was approved for the control of certain diabetic complications.

While it was approved for marketed in several countries, it failed a Phase III trial in the U.S. due to toxicity and never received FDA approval. It was discontinued by Wyeth in 1997 because of the risk of severe liver toxicity and death. It was sold under the tradename Alredase.