California rocket fuel

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“California rocket fuel” is a medical slang term for the combined administration of mirtazapine (a NaSSA) and venlafaxine (an SNRI).[1] This combination is usually used in the treatment of severe and/or treatment-resistant depression and may have efficacy superior to the MAOI tranylcypromine (though the advantage was not statistically significant in this study), with fewer side effects and better tolerability.[2] However, when used as an initial treatment, the mirtazapine and venlafaxine combination resulted in more than twice the remission rate of single antidepressant therapy with the SSRI fluoxetine.[3]

References

  1. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Combination of Antidepressant Medications From Treatment Initiation for Major Depressive Disorder: A Double-Blind Randomized Study


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