Demoxepam
From Infogalactic: the planetary knowledge core
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Systematic (IUPAC) name | |
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7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one-4-oxide
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Pharmacokinetic data | |
Biological half-life | 35–40 hours |
Identifiers | |
CAS Number | 963-39-3 ![]() |
PubChem | CID: 13756 |
ChemSpider | 10441314 ![]() |
UNII | 8X1XP5M0SB ![]() |
KEGG | D02600 ![]() |
ChEMBL | CHEMBL1597677 ![]() |
Chemical data | |
Formula | C15H11ClN2O2 |
Molecular mass | 286.713 |
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Demoxepam[1] is a drug which is a benzodiazepine derivative. It is a metabolite of chlordiazepoxide and has anticonvulsant properties[2][3] and presumably other characteristic benzodiazepine properties.
Synthesis
Demoxepam is also an intermediate in the synthesis of oxazepam; it is also used in one of the syntheses of medazepam. It can be considered directly analogous/synonoymous with the synthesis of chlordiazepoxide, with the exception that instead of methylamine, hydroxide ion is the choice of base; here acid is not used for the cyclodehydration step though.
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Demoxepam synthesis: Reeder Earl, Sternbach Leo Henryk, U.S. Patent 3,136,815 (1959 to Hoffmann La Roche).
See also
References
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Categories:
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