Minaxolone
From Infogalactic: the planetary knowledge core
Systematic (IUPAC) name | |
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(2β,3α,5α,11α)-11-(dimethylamino)-2-ethoxy-3-hydroxypregnan-20-one
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Identifiers | |
CAS Number | 62571-87-3 |
ATC code | none |
PubChem | CID: 71960 |
IUPHAR/BPS | 5478 |
ChemSpider | 64967 |
UNII | 737SKC73L0 |
KEGG | D05041 |
ChEMBL | CHEMBL2105209 |
Synonyms | 1-[(1S,2S,4S,5S,7S,10S,11S,14S,15S,17R)-17-(dimethylamino)-4-ethoxy-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadecan-14-yl]ethan-1-one |
Chemical data | |
Formula | C25H43NO3 |
Molecular mass | 405.614 g/mol |
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Minaxolone (CCI-12923) is a neuroactive steroid which was developed as a general anesthetic but was withdrawn before registration due to toxicity seen with long-term administration in rats, and hence was never marketed.[1][2][3] It is a positive allosteric modulator of the GABAA receptor,[4] as well as, less potently, a positive allosteric modulator of the glycine receptor.[4][5]
See also
References
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Categories:
- Chemical articles having calculated molecular weight overwritten
- Articles with changed InChI identifier
- Infobox drug articles without a structure image
- Chemical pages without DrugBank identifier
- Drugs not assigned an ATC code
- Drugs with no legal status
- General anesthetics
- Neurosteroids
- Alcohols
- Ethers
- Amines
- Ketones
- GABAA receptor positive allosteric modulators
- Glycine receptor agonists
- Nervous system drug stubs