Girisopam

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Girisopam
Girisopam.svg
Systematic (IUPAC) name
1-(3-chlorophenyl)-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine
Identifiers
CAS Number 82230-53-3 YesY
ATC code none
PubChem CID: 71257
ChemSpider 64387 YesY
UNII 2LP301A921 YesY
ChEMBL CHEMBL1915065 N
Chemical data
Formula C18H17ClN2O2
Molecular mass 328.79
  • Clc3cccc(C\2=N\N=C(/Cc1c/2cc(OC)c(OC)c1)C)c3
  • InChI=1S/C18H17ClN2O2/c1-11-7-13-9-16(22-2)17(23-3)10-15(13)18(21-20-11)12-5-4-6-14(19)8-12/h4-6,8-10H,7H2,1-3H3 YesY
  • Key:VQYLGVVODFDFNK-UHFFFAOYSA-N YesY
 NYesY (what is this?)  (verify)

Girisopam[1] (GYKI-51189) is a drug which is a 2,3-benzodiazepine derivative, related to tofisopam[2] and zometapine. It has selective anxiolytic action with no sedative, anticonvulsant or muscle relaxant effects.[3][4][5]

See also

References

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  1. ↑ US Patent 4322346
  2. ↑ Psychotropics.dk
  3. ↑ Andrási F, Horváth K, Sineger E, Berzsenyi P, Borsy J, Kenessey A, Tarr M, Láng T, Kórösi J, Hámori T. Neuropharmacology of a new psychotropic 2,3-benzodiazepine. Arzneimittelforschung. 1987 Oct;37(10):1119-24.
  4. ↑ Horváth K, Andrási F, Botka P, Hámori T. Anxiolytic profile of girisopam and GYKI 52,322 (EGIS 6775). Comparison with chlordiazepoxide and buspirone. Acta Physiologica Hungarica. 1992;79(2):153-61.
  5. ↑ Horváth EJ, Salamon C, Bakonyi A, Fekete MI, Palkovits M. [(3)H]-girisopam, a novel selective benzodiazepine for the 2, 3-benzodiazepine binding site. Brain Research. Brain Research Protocols. 1999 Jul;4(2):230-5.
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