Difluocortolone valerate

Difluocortolone valerate

Names
IUPAC name (6α,11β,16α)-6,9-Difluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl pentanoate
Other names Afusona; Diflucortolone 21-valerate
Identifiers
CAS Number	59198-70-8 Y
ChEMBL	ChEMBL65702
ChemSpider	82773 Y
Jmol 3D model	Interactive image
PubChem	91670
InChI InChI=1S/C27H36F2O5/c1-5-6-7-23(33)34-14-21(31)24-15(2)10-17-18-12-20(28)19-11-16(30)8-9-26(19,4)27(18,29)22(32)13-25(17,24)3/h8-9,11,15,17-18,20,22,24,32H,5-7,10,12-14H2,1-4H3/t15-,17+,18+,20+,22+,24-,25+,26+,27+/m1/s1 Y Key: HHJIUUAMYGBVSD-YTFFSALGSA-N Y InChI=1/C27H36F2O5/c1-5-6-7-23(33)34-14-21(31)24-15(2)10-17-18-12-20(28)19-11-16(30)8-9-26(19,4)27(18,29)22(32)13-25(17,24)3/h8-9,11,15,17-18,20,22,24,32H,5-7,10,12-14H2,1-4H3/t15-,17+,18+,20+,22+,24-,25+,26+,27+/m1/s1 Key: HHJIUUAMYGBVSD-YTFFSALGBY
SMILES O=C(OCC(=O)[C@@H]3[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](F)C[C@H]4[C@@H]2C[C@H]3C)C)C)CCCC
Properties
Chemical formula	C27H36F2O5
Molar mass	478.58 g·mol−1
Melting point	220 °C (428 °F; 493 K)
Vapor pressure	{{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Difluocortolone valerate (also Nerisone cream/oily cream/ointment, Neriderm ointment, Japanese ジフルコルトロン (Jifurucorutoron) is a corticosteroid rated Class 2 "potent" (100-150 times) in the New Zealand topical steroid system. It is a white to creamy white crystalline powder. It is practically insoluble in water, freely soluble in dichloromethane and in dioxan, sparingly soluble in ether and slightly soluble in methyl alcohol. Chemically, it is a corticosteroid esterified with valeric acid. It is commonly used topically in dermatology. The brand name is Nerisone; its creams come in potencies of 0.1% and 0.3%.

See also

• Difluocortolone