Flumetasone

Flumetasone

Systematic (IUPAC) name
(1R,2S,8S,10S,11S,13R,14R,15S,17S)-1,8-difluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of administration	Topical
Pharmacokinetic data
Metabolism	Hepatic, CYP3A4-mediated
Identifiers
CAS Number	2135-17-3 Y
ATC code	D07AB03 (WHO) , D07XB01 (combinations), QH02AB90 (WHO)
PubChem	CID: 16490
UNII	LR3CD8SX89 N
KEGG	D04208 Y
ChEMBL	CHEMBL1201392 N
Synonyms	Flumethasone
Chemical data
Formula	C22H28F2O5
Molecular mass	410.452 g/mol
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Flumetasone (INN; or flumethasone) is a corticosteroid for topical use. Trade names include Locacorten, Locorten, and Orsalin. It is available in combination with clioquinol, under the trade name Locacorten-Vioform (in some countries Locorten-Vioform), for the treatment of otitis externa and otomycosis. It is usually formulated as the pivalic acid ester prodrug flumetasone pivalate.

Flumethasone is 420 times as potent as cortisone in an animal model for anti-inflammatory activity.

See also

• Glucocorticoid
• Corticosteroid
• Triamcinolone acetonide