JWH-302

JWH-302

Systematic (IUPAC) name
2-(3-methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone
Identifiers
CAS Number	864445-45-4 N
PubChem	CID: 11493740
ChemSpider	9668546 Y
ChEMBL	CHEMBL186674 Y
Chemical data
Formula	C22H25NO2
Molecular mass	335.439 g/mol
SMILES c2ccc(OC)cc2CC(=O)c(cn1CCCCC)c3ccccc13
InChI InChI=1S/C22H25NO2/c1-3-4-7-13-23-16-20(19-11-5-6-12-21(19)23)22(24)15-17-9-8-10-18(14-17)25-2/h5-6,8-12,14,16H,3-4,7,13,15H2,1-2H3 Y Key:XZVYWLVYUAQEIM-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

JWH-302 or (1-pentyl-3-(3-methoxyphenylacetyl)indole) is an analgesic chemical from the phenylacetylindole family, which acts as a cannabinoid agonist with moderate affinity at both the CB₁ and CB₂ receptors. It is a positional isomer of the more common drug JWH-250, though it is slightly less potent with a K_i of 17nM at CB₁, compared to 11nM for JWH-250. Because of their identical molecular weight and similar fragmentation patterns, JWH-302 and JWH-250 can be very difficult to distinguish by GC-MS testing.