Org 27569
From Infogalactic: the planetary knowledge core
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Systematic (IUPAC) name | |
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5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)ethyl]amide
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Identifiers | |
CAS Number | 868273-06-7 ![]() |
PubChem | CID: 44828492 |
IUPHAR/BPS | 7851 |
ChemSpider | 22369629 ![]() |
Chemical data | |
Formula | C24H28ClN3O |
Molecular mass | 409.951 g/mol |
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Org 27569 is a drug which acts as a potent and selective positive allosteric modulator of the cannabinoid CB1 receptor. Studies in vitro suggest that it binds to a regulatory site on the CB1 receptor target, causing a conformational change that increases the binding affinity of CB1 agonists such as CP 55,940, while decreasing the binding affinity of CB1 antagonists or inverse agonists such as rimonabant. However while Org 27569 increases the ability of CB1 agonists to bind to the receptor, it decreases their efficacy at stimulating second messenger signalling once bound, and so in practice behaves as an insurmountable antagonist of CB1 receptor function.[1]
See also
References
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Categories:
- Chemical articles having calculated molecular weight overwritten
- Infobox drug articles without a structure image
- Articles without EBI source
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- Drugboxes with an unspecified ATC code
- Drugs with no legal status
- Cannabinoids
- CB1 receptor antagonists
- Cannabinoid stubs