L-759,633

L-759,633

Systematic (IUPAC) name
(6aR,10aR)-1-methoxy-6,6,9-trimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromene
Identifiers
PubChem	CID: 5311215
IUPHAR/BPS	748
ChemSpider	4470734 N
ChEMBL	CHEMBL57367 N
Chemical data
Formula	C26H40O2
Molecular mass	384.593 g/mol
SMILES CCCCCCC(C)(C)c1cc2c(c(c1)OC)[C@@H]3CC(=CC[C@H]3C(O2)(C)C)C
InChI InChI=1S/C26H40O2/c1-8-9-10-11-14-25(3,4)19-16-22(27-7)24-20-15-18(2)12-13-21(20)26(5,6)28-23(24)17-19/h12,16-17,20-21H,8-11,13-15H2,1-7H3/t20-,21-/m1/s1 N Key:SUFMHSFGODDLKI-NHCUHLMSSA-N N
NY (what is this?)  (verify)

L-759,633 is an analgesic drug that is a cannabinoid agonist. It is a fairly selective agonist for the CB₂ receptor, with selectivity of 163x for CB₂ over CB₁.

It produces some similar effects to other cannabinoid agonists such as analgesia, but with little or no sedative or psychoactive effects due to its weak CB₁ activity, and a relatively strong antiinflammatory effect due to its strong activity at CB₂.

See also

• L-759,656
• L-768,242