Broparestrol

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Broparestrol (INN) (brand names Acnestrol, Longestrol), also known as α-bromo-α,β-diphenyl-β-p-ethylphenylethylene (BDPE), is a synthetic, non-steroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group[1] that is or was used in Europe as a dermatological agent and for the treatment of breast cancer.[2][3][4][5] The drug is described as slightly estrogenic[6] and potently antiestrogenic,[7][8] and inhibits mammary gland development and suppresses prolactin levels in animals.[9] It is structurally related to clomifene and diethylstilbestrol.[5][9]

Broparestrol is a mixture of E- and Z- isomers (LN-1643 and LN-2299, respectively), both of which are active and are similarly antiestrogenic but, unlike broparestrol, were never marketed.[2]

See also

References

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