Estropipate

"Ogen" redirects here. For the character in the Japanese anime, see Ogen (Basilisk).

Estropipate

Systematic (IUPAC) name
[(8R,9S,13S,14S)-13-Methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] hydrogen sulfate; piperazine
Clinical data
AHFS/Drugs.com	monograph
Identifiers
CAS Number	7280-37-7 N
ATC code	none
PubChem	CID: 5284555
DrugBank	DB04574 Y
ChemSpider	4447610 Y
UNII	SVI38UY019 Y
KEGG	D00948 Y
ChEMBL	CHEMBL1200980 N
Chemical data
Formula	C22H32N2O5S
Molecular mass	436.56 g/mol
SMILES O=S(=O)(O)Oc1cc4c(cc1)[C@@H]3[C@H]([C@@H]2CCC(=O)[C@@]2(C)CC3)CC4.N1CCNCC1
InChI InChI=1S/C18H22O5S.C4H10N2/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;1-2-6-4-3-5-1/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22);5-6H,1-4H2/t14-,15-,16+,18+;/m1./s1 Y Key:HZEQBCVBILBTEP-ZFINNJDLSA-N Y
NY (what is this?)  (verify)

Estropipate (INN, BAN) (brand names Ogen, Ortho-Est), also known as piperazine estrone sulfate, is a synthetic, steroidal estrogen. It is a salt of estrone sulfate and piperazine.

Uses

Estropipate is used to:

• Alleviate symptoms of menopause as hormone replacement therapy
• Treat some types of infertility
• Treat some conditions leading to underdevelopment of female sexual characteristics
• Treat vaginal atrophy
• Treat some types of breast cancer (particularly in men and postmenopausal women)
• Treat prostate cancer
• Prevent osteoporosis

Pharmacology

Estropipate is an agonist of the estrogen receptor (ER). In addition, estropipate has been found to act as an inhibitor of OATP1B1 (IC₅₀ = 70 nM).[1]

See also

• Estrogen ester