FCGR3B

Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
250px PDB rendering based on 1e4j.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1E4J, 1E4K, 1FNL, 1T83, 1T89
Identifiers
Symbols	FCGR3B ; CD16; CD16b; FCG3; FCGR3; FCR-10; FCRIII; FCRIIIb
External IDs	OMIM: 610665 HomoloGene: 477 ChEMBL: 5842 GeneCards: FCGR3B Gene
Gene ontology Molecular function • IgG binding Cellular component • plasma membrane • anchored component of membrane • extracellular exosome Biological process • positive regulation of defense response to virus by host • immune response • activation of mitophagy in response to mitochondrial depolarization Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE FCGR3B 204007 at tn.png
File:PBB GE FCGR3B 204006 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2215	246256
Ensembl	ENSG00000162747	ENSMUSG00000059089
UniProt	O75015	n/a
RefSeq (mRNA)	NM_000570	NM_144559
RefSeq (protein)	NP_000561	NP_653142
Location (UCSC)	Chr 1: 161.62 – 161.63 Mb	Chr 1: 171.02 – 171.03 Mb
PubMed search	[1]	[2]

FCGR3B (Fc fragment of IgG, low affinity IIIb, receptor), also known as CD16b (Cluster of Differentiation 16b), is a human gene.

Clinical relevance

Mutations and copy-number variations in this gene have been associated to clinical cases of glomerulonephritis.

See also

• CD16
• Cluster of differentiation

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.