CXCR6

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Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). C-X-C chemokine receptor type 6 is a protein that in humans is encoded by the CXCR6 gene.[1][2][3] CXCR6 has also recently been designated CD186 (cluster of differentiation 186).

CXCR6 has been identified as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4.[1][2][3][4] It is a minor coreceptor for HIV-1, nearly all strains of which use CCR5 and/or CXCR4. Most SIV strains can use CXCR6 and recent evidence suggests that in monkeys that serve as the natural hosts of SIV, CXCR6 may be a major coreceptor.[4] CXCR6 was previously known as "Bonzo" and "STRL33" in the HIV/SIV field.

References

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Further reading

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External links

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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