Poliovirus receptor-related 2

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Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Poliovirus receptor-related 2 (PVRL2), also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), is a human plasma membrane glycoprotein.[1]

Function

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[1]

See also

References

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Further reading

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External links

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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