miR-296
| miR-296 | |
|---|---|
| 220px | |
| Conserved secondary structure of miR-296 microRNA precursor | |
| Identifiers | |
| Symbol | miR-296 |
| Alt. Symbols | MIR296 |
| Rfam | RF00733 |
| miRBase | MI0000747 |
| miRBase family | MIPF0000159 |
| Entrez | 407022 |
| HUGO | 31617 |
| OMIM | 610945 |
| RefSeq | NR_029844 |
| Other data | |
| RNA type | miRNA |
| Domain(s) | Mammalia |
| GO | 0035195 |
| SO | 0001244 |
| Locus | Chr. 20 q13.32 |
miR-296 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer.[1] This sequence then associates with RISC which effects RNA interference.[2]
miR-296 has been named an "angiomiR"[3] due to being characterised as a microRNA which regulates angiogenesis, the process of growth and creation of new blood vessels.[4] miR-296 is thought to have a specific role in cancer in promoting tumour angiogenesis.[3][5] It achieves this by targeting HGS mRNA, reducing its expression in endothelial cells which then results in greater number of VEGF receptors.[3][6]
miR-296 has predicted target sites in the transcription factor NANOG[7] and may also contribute to carcinogenesis by dysregulating p53.[8]
References
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