miR-338
| miR-338 | |
|---|---|
| 220px | |
| Conserved secondary structure of miR-338 microRNA precursor | |
| Identifiers | |
| Symbol | miR-338 |
| Alt. Symbols | MIR338 |
| Rfam | RF00686 |
| miRBase | MI0000814 |
| miRBase family | MIPF0000097 |
| Entrez | 442906 |
| HUGO | 31775 |
| OMIM | 614059 |
| RefSeq | NR_029897 |
| Other data | |
| RNA type | miRNA |
| Domain(s) | Mammalia |
| GO | 0035195 |
| SO | 0001244 |
| Locus | Chr. 17 q25.3 |
miR-338 is a family of brain-specific microRNA precursors found in mammals, including humans.[1] The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer.[2] This sequence then associates with RISC which effects RNA interference.[3]
miR-338 is located in an intronic region within the gene for apoptosis-associated tyrosine kinase (AATK). It has been predicted that it may downregulate genes which have a downstream negative effect on AATK expression.[4]
Function
miR-338 is a brain-specific miRNA which regulates the expression of cytochrome c oxidase IV (COX4).[1][5] The mature miR-338 miRNA sequence is complementary to a short section of the 3' untranslated region of COX4 mRNA. This mRNA sequence is presented atop a stem-loop structure, indicating it is accessible to miRNA processing.[5]
Applications
miR-338 is dysregulated in neuroblastoma, and could potentially be implemented as a biomarker or future therapeutic agent.[6] miR-338 has also been linked with hepatocellular carcinoma, and a large-scale diagnostic test has been suggested involving measurement of miR-338 expression in tissue samples.[7] Furthermore, miR-338 is one of seven microRNAs whose expression profiles can be combined to give a prediction of the probability of survival of a patient with gastric cancer.[8]
References
- ↑ 1.0 1.1 Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ 5.0 5.1 Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
Further reading
- Lua error in package.lua at line 80: module 'strict' not found. (Chinese)
- Lua error in package.lua at line 80: module 'strict' not found.
