mir-BHRF1-1 microRNA precursor family
| mir-BHRF1-1 microRNA precursor family | |
|---|---|
| 220px | |
| Predicted secondary structure and sequence conservation of mir-BHRF1-1 | |
| Identifiers | |
| Symbol | mir-BHRF1-1 |
| Rfam | RF00365 |
| Other data | |
| RNA type | Gene; miRNA |
| Domain(s) | Viruses |
| GO | 0035195 0035068 |
| SO | 0001244 |
The mir-BHRF1-1 microRNA precursor found in Human herpesvirus 4 (Epstein-Barr virus) and Cercopithicine herpesvirus 15. In Epstein-Barr virus, mir-BHRF1-1 is found in the 5' UTR of the BHRF1 (Bam HI fragment H rightward open reading frame 1) gene, which is known to encode a distant Bcl-2 homolog. The mature sequence is excised from the 5' arm of the hairpin.[1] Two other miRNA precursors were found in this reading frame, namely Mir-BHRF1-2 and Mir-BHRF1-3.[1]
BHRF-1-1 miRNA is thought to operate as part of a 'miRNA cluster' with two other microRNAs also found in the Epstein-Barr virus genome.[2] BHRF-1-1 has been shown to be expressed in latency-III infected lymphoblasts.[3]
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