mir-145
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| mir-145 | |
|---|---|
| 220px | |
| Conserved secondary structure of mir-145 | |
| Identifiers | |
| Symbol | mir-145 |
| Rfam | RF00675 |
| miRBase family | MIPF0000079 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
In molecular biology, mir-145 microRNA is a short RNA molecule that in humans is encoded by the MIR145 gene. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.[1]
Targets
MicroRNAs are involved in down-regulation of a variety of target genes. Götte et al. have shown that experimental over-expression of mir-145 down-regulates the junctional cell adhesion molecule JAM-A as well as the actin bundling protein fascin.[2] Larsson et al.[3] showed that miR-145 targets the 3' UTR of the FLI1 gene, a finding that was later supported by Zhang et al.[4]
Role in cancer
miR-145 is hypothesised to be a tumor suppressor.[5] miR-145 has been shown to be down-regulated in breast cancer.[2] miR-145 is also involved in colon cancer [4][6] and acute myeloid leukemia.[7]
References
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Further reading
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