mir-24 microRNA precursor family
| mir-24 microRNA precursor family | |
|---|---|
| 220px | |
| Predicted secondary structure and sequence conservation of mir-24 | |
| Identifiers | |
| Symbol | mir-24 |
| Rfam | RF00178 |
| miRBase | MI0000080 |
| miRBase family | MIPF0000041 |
| Other data | |
| RNA type | Gene; miRNA |
| Domain(s) | Eukaryota |
| GO | 0035195 0035068 |
| SO | 0001244 |
The miR-24 microRNA precursor is a small non-coding RNA molecule that regulates gene expression. microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a mature ~22 nucleotide product. In this case the mature sequence comes from the 3' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA. miR-24 is conserved in various species, and is clustered with miR-23 and miR-27, on human chromosome 9 and 19.[1] Recently, miR-24 has been shown to suppress expression of two crucial cell cycle control genes, E2F2 and Myc in hematopoietic differentiation [2] and also to promote keratinocyte differentiation by repressing actin-cytoskeleton regulators PAK4, Tsk5 and ArhGAP19.[3]
Targets of miR-24
- Lal et al. suggested that miR-24 suppresses the tumor suppressor p16(INK4a).[1]
- Lal et al. reported that mi-24 inhibits cell proliferation by targeting E2F2, MYC via binding to "seedless" 3'UTR microRNA recognition elements.[2]
- Amelio I. et al. suggest that miR-24 regulates keratinocyte differentiation, controlling actin-cytoskeleton dynamics via PAK4, Tsk5 and ArhGAP19 repression.[3]
- Wang et al.. have shown that miR-24 reduces the mRNA and protein levels of human ALK4 by targeting the 3'-untranslated region of mRNA.[4]
- Mishra et al. suggest that miR-24 targets the DHFR gene.[5]
References
- ↑ 1.0 1.1 Lua error in package.lua at line 80: module 'strict' not found.
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External links
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