mir-9/mir-79 microRNA precursor family

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mir-9
RF00237.jpg
miR-9 microRNA secondary structure and sequence conservation.
Identifiers
Symbol mir-9
Rfam RF00237
miRBase family MIPF0000014
HUGO 31641
OMIM 611186
Other data
RNA type microRNA
Domain(s) Eukaryota;

The miR-9 microRNA (homologous to miR-79), is a short non-coding RNA gene involved in gene regulation. The mature ~21nt miRNAs are processed from hairpin precursor sequences by the Dicer enzyme. The dominant mature miRNA sequence is processed from the 5' arm of the mir-9 precursor, and from the 3' arm of the mir-79 precursor. The mature products are thought to have regulatory roles through complementarity to mRNA.[1] In vertebrates, miR-9 is highly expressed in the brain, and is suggested to regulate neuronal differentiation.[2] A number of specific targets of miR-9 have been proposed, including the transcription factor REST and its partner CoREST.[3]

Species distribution

miR-9 has been identified in Drosophila (MI0000129),[4] mouse (MI0000720) and human (MI0000466),[5] and the related miR-79 in C. elegans (MI0000050) [6] and Drosophila melanogaster (MI0000374).[7]

Role in disease

microRNAs have been implicated in human cancer in a number of studies. It has been shown that human miR-9 expression levels are reduced in many breast cancer samples due to hypermethylation an epigenetic modification.[8] Hildebrandt et al. show that two genes encoding for hsa-miR-9 are significantly hypermethylated in clear cell renal carcinoma tumours.[9]

References

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Further reading

[10] [11] [12] [13] [14] [15] [16] [17] [18] [19] [20] [21] [22] [23] [24] [25] [3] [26] [27] [28] [29] [30] [31] [32] [8] [33]

External links

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