HOXA13
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Homeobox protein Hox-A13 is a protein that in humans is encoded by the HOXA13 gene.[1][2][3]
Contents
Function
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation.[3]
Clinical significance
Expansion of a polyalanine tract in the encoded protein can cause hand-foot-genital syndrome , also known as hand-foot-uterus syndrome.[4]
See also
References
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External links
- GeneReviews/NCBI/NIH/UW entry on Hand-Foot-Genital Syndrome
- HOXA13 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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