KLF4
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Kruppel-like factor 4 (KLF4) is a member of the KLF family of transcription factors and regulates proliferation, differentiation, apoptosis and somatic cell reprogramming. Evidence also suggests that KLF4 is a tumor suppressor in certain cancers, including Colorectal cancer.[1]
In embryonic stem cells (ESCs), KLF4 has been demonstrated to be a good indicator of stem-like capacity. It is suggested that the same is true in mesenchymal stem cells (MSCs).
In humans, the protein is encoded by the KLF4 gene.[2] The KLF4 gene is conserved in chimpanzee, rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.[3]
Interactions
KLF4 has been shown to interact with CREB-binding protein.[4]
It was found that the transcription factor Klf4 present at the promoter of an enzymatic subunit of telomerase (TERT), where it formed a complex with β-catenin. Klf4 was required for accumulation of β-catenin at the Tert promoter but was unable to stimulate Tert expression in the absence of β-catenin.[5]
See also
References
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External links
- KLF4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- KLF4 microarray expression results and literature
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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