PAX9
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Paired box gene 9, also known as PAX9, is a protein which in humans is encoded by the PAX9 gene.[1][2] It is also found in mammals generally.[3]
Contents
Function
This gene is a member of the paired box (PAX) family of transcription factors. PAX9 is responsible for tooth development[3] and may more generally involve development of stratified squamous epithelia as well as various organs and skeletal elements.[1] PAX9 plays a role in the absence of wisdom teeth in some human populations (possibly along with the less well studied AXIN2 and MSX1).[3]
Clinical significance
This gene was found amplified in lung cancer. The amplification covers three tissue developmental genes - TTF1, NKX2-8, and PAX9.[4] It appears that certain lung cancer cells select for DNA copy number amplification and increased RNA/protein expression of these three coamplified genes for functional advantages.
Interactions
PAX9 has been shown to interact with JARID1B.[5]
References
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External links
- PAX9 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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