SPI1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Transcription factor PU.1 is a protein that in humans is encoded by the SPI1 gene.[1]
Function
This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development.[Citation needed] The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene.[2]
Interactions
SPI1 has been shown to interact with:
See also
References
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<references />, or <references group="..." />Further reading
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External links
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This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it. |
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